Jamie Rellis (Mila Kunis) is a New York City head-hunter trying to sign Los Angeles-based art director Dylan Harper (Justin Timberlake) for her client. When he takes the job and makes the move, they quickly become friends. Their friendship turns into a friendship with benefits, but with Jamie's emotionally damaged past and Dylan's history of being emotionally unavailable, they have to try to not fall for each other the way Hollywood romantic comedies dictate.

Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone. Mutant victims of the plague -- The Infected -- lurk in the shadows... watching Neville's every move... waiting for him to...